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Wisdom Panel 2.0
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Wisdom Panel® 3.0

PRICE: £75.00
 

Description+

The Mars Veterinary team of scientists and geneticists have been researching and developing canine DNA tests for nearly 10 years making Wisdom Panel canine DNA tests the most comprehensive breed analysis tests in the world. Mars Veterinary holds the worldwide exclusive license for use of the patented breed analysis process from the Fred Hutchinson Cancer Research Institute and has tested more than 750,000 dogs.

The Wisdom Panel 3.0 test provides the following:

  • Screening for more than 200 breeds and varieties
  • Identification of purebred ancestors present in the first three generations (to the great-grandparent level)
  • A predicted weight profile
  • Screening for the MDR1 genetic mutation that can affect sensitivity towards common drugs

Wisdom Panel 3.0 covers more than 200 breeds, types and varieties including all those recognized by The Kennel Club and can be run for mixed-breed, designer, or purebred dogs. The procedure is the same for all three, but you decide at the time of activation how you would like us to run it. For purebred and designer dogs, the test will provide an additional Principle Component Analysis chart comparing your dog with others of that same breed(s) in our database and for purebred tests specifically, an additional Homozygosity Profile.

The Wisdom Panel 3.0 Canine DNA Test kit includes:

  • Instructions
  • DNA cheek swabs – both for use on one dog
  • Pre-paid shipping label and envelope

Disease Testing – MDR1+

For many years now Wisdom Panel has provided genetic mutation tests through our veterinary products and now we are including one of these important tests in our at-home swab product. Included in the Wisdom Panel 3.0 and 4.0 Canine Genetic Tests is the MDR1 genetic mutation test licensed from Washington State University, for use by Mars Veterinary.


MDR1 or Multi-Drug Resistance 1 is a genetic mutation found in many of the herding breeds, some sighthound breeds, and many mixed breed dogs. The MDR1 gene is responsible for production of a protein called P-glycoprotein. The P-glycoprotein molecule is a drug transport pump that plays an important role in limiting drug absorption and distribution (particularly to the brain) and enhancing the excretion/elimination of many drugs used in dogs.


Some dogs, particularly herding breeds or mixed-breed dogs with herding breed ancestry have a mutation in the MDR1 gene that makes them defective in their ability to limit the absorption and distribution of many drugs. These dogs are also slower to eliminate drugs from the body that are transported by P-glycoprotein. As a result, dogs with the MDR1-mutation may have severe adverse reactions to some common drugs, so it is important to test your dog and share your results with your veterinarian so they can provide your dog with for the best possible care.


What About Mixed-breed Dogs?
Our tests look for the presence of purebreds in your dog’s heritage back to the great-grandparent level. Just because we don’t find a pedigree herding breed in your dog’s last three generations, however, doesn’t mean he or she doesn’t have one further back in their ancestry. Therefore, even mixed breed dogs should be tested for the MDR1 mutation. The results of this test can give owners with mixed-breed ancestry important information to share with their veterinarian or better yet…peace of mind.


Drugs Affected By The MDR1 Mutation:

  • Acepromazine
  • Butorphanol
  • Doxorubicin
  • Doramectin
  • Emodepside
  • Erythromycin
  • Ivermectin
  • Loperamide
  • Milbemycin
  • Moxidectin
  • Paclitaxel
  • Rifampin
  • Selamectin
  • Vinblastine
  • Vincristine

    Drugs Affected By The MDR1 Mutation (frequency %)

    • Australian Shepherd 50%
    • Australian Shepherd, Mini 50%
    • Border Collie < 5%
    • Collie 70 %
    • English Shepherd 15 %
    • German Shepherd 10 %
    • Herding Breed Cross 10 %
    • Long-haired Whippet 65 %
    • McNab 30 %
    • Mixed Breed 5 %
    • Old English Sheepdog 5 %
    • Shetland Sheepdog 15 %
    • Silken Windhound 30 %
    FAQS ABOUT MDR1

    Can Collie crosses or other herding breed crosses carry the mutant MDR1 gene and have an adverse reaction to a normal dose of some drugs?

    Yes, it is less likely in a mixed breed, but still possible. For example, the mutant gene was found in a Saint Bernard mix that had an adverse drug reaction. The veterinarian did note that each eye was a different colour, like some Australian Shepherds.

    How old must a dog be before it can be tested?

    Just like breed testing, a puppy can be tested as soon as it is weaned from its mother. We recommend waiting until the puppy is weaned, because the sample is collected from inside the dog's mouth, and milk can contain a cells from the mother. Therefore, it is possible that the puppy's sample could contain enough of the mother’s DNA to generate a false result.

     

    Can mixed breed dogs have the MDR1 mutation?

    YES! The MDR1 mutation has been found in many mixed breed dogs - even dogs that don't look like herding breed dogs. In particular mixed breed dogs should be tested for the mutation before receiving therapies for some common parasitic diseases, such as Demodectic mange.

    What heartworm prevention products can I use if my dog has the MDR1 mutation?

    Always consult with your veterinarian before administering any drugs to your dog. Fortunately, the doses of ivermectin, selamectin, milbemycin and moxidectin in the FDA approved heartworm prevention preparations are low enough to be used safely even in dogs that have two copies of the MDR1 mutation. It is only when these drugs are administered at high doses that dogs with the mutation will develop signs of toxicity. Attempting to use formulations of these drugs approved for use in large animals will increase the risk of overdosing the dog and causing severe toxicity, because it is difficult to accurately measure the small doses needed for dogs using these large animal formulations.


    ORIGINS OF THE TEST

    The discovery of the mutation of the multi-drug resistant gene (MDR1) and its effects on multidrug sensitivity in dogs was made by Washington State University. It is a patent-protected diagnostic test offered by Washington State University that has been licensed to Mars Veterinary for use in the Wisdom Panel tests.

    Breeds Detected+

    As the leader in canine breed detection, Wisdom Panel 3.0 features the largest breed database on the market providing superior accuracy in breed results.
     
    Don’t see your breed? Our database was developed using genetic markers from American Kennel Club (AKC) and Kennel Club breeds in the UK. If you believe your dog to be a breed or mix of breeds not found on this list note that his or her results may either show a mixed breed ancestor or the closest genetically related breed(s).
     
    • Affenpinscher
      Afghan Hound
      Airedale Terrier
      Akita
      Alaskan Klee Kai
      Alaskan Malamute
      American Bulldog
      American Eskimo Dog
      American Foxhound
      American Staffordshire Terrier
      American Water Spaniel
      Anatolian Shepherd Dog
      Argentine Dogo
      Australian Cattle Dog
      Australian Kelpie
      Australian Koolie
      Australian Shepherd
      Australian Terrier
      Azawakh
      Basenji
      Basset Hound
      Beagle
      Bearded Collie
      Beauceron
      Bedlington Terrier
      Belgian Malinois
      Belgian Sheepdog
      Belgian Tervuren
      Bergamasco
      Berger Picard
      Bernese Mountain Dog
      Bichon Frise
      Biewer Terrier
      Black and Tan Coonhound
      Black Russian Terrier
      Bloodhound
      Bluetick Coonhound
      Bolognese
      Border Collie
      Border Terrier
      Borzoi
      Boston Terrier
      Bouvier des Flandres
      Boxer
      Boykin Spaniel
      Briard
      Brittany
      Brussels Griffon
      Bull Terrier
      Bulldog
      Bullmastiff
      Cairn Terrier
      Canaan Dog
      Cane Corso
      Cardigan Welsh Corgi
      Cavalier King Charles Spaniel
      Cesky Terrier
      Chesapeake Bay Retriever
      Chihuahua
      Chinese Crested
      Chinese Shar-Pei
      Chinook
      Chow Chow
      Cirneco dell'Etna
      Clumber Spaniel
      Cocker Spaniel
      Collie
      Coton de Tulear
      Curly-Coated Retriever
      Dachshund Miniature Longhaired
      Dachshund Miniature Shorthaired
      Dachshund Miniature Wirehaired
      Dachshund Standard Longhaired
      Dachshund Standard Shorthaired
      Dachshund Standard Wirehaired
      Dalmatian
      Dandie Dinmont Terrier
      Doberman Pinscher
      Dogue de Bordeaux
      English Cocker Spaniel
      English Foxhound
      English Setter
      English Springer Spaniel
      English Toy Spaniel
      Entlebucher Mountain Dog
      Field Spaniel
      Finnish Lapphund
      Finnish Spitz
      Flat-Coated Retriever
      French Bulldog
      German Pinscher
      German Shepherd (White Swiss Shepherd)
      German Shepherd Dog
      German Shorthaired Pointer
      German Spitz
      German Wirehaired Pointer
      Giant Schnauzer
      Glen of Imaal Terrier
      Golden Retriever
      Gordon Setter
      Grand Basset Griffon Vendéen
      Great Dane
      Great Pyrenees
      Greater Swiss Mountain Dog
      Greyhound
      Harrier
      Havanese
      Ibizan Hound
      Icelandic Sheepdog
      Irish Red and White Setter
      Irish Setter
      Irish Terrier
      Irish Water Spaniel
      Irish Wolfhound
      Italian Greyhound
      Japanese Chin
      Japanese Spitz
      Jindo
      Keeshond
      Kerry Blue Terrier
      Komondor
      Kuvasz
      Labrador Retriever
      Lagotto Romagnolo
      Lakeland Terrier
      Lancashire Heeler
      Large Münsterlander
      Leonberger
      Lhasa Apso
      Löwchen
      Magyar Agár
      Maltese
      Manchester Terrier
      Maremma Sheepdog
      Mastiff
      Mi-ki
      Miniature Bull Terrier
      Miniature Pinscher
      Miniature Poodle
      Miniature Schnauzer
      Mudi
      Neapolitan Mastiff
      Newfoundland
      Norfolk Terrier
      Norwegian Buhund
      Norwegian Elkhound
      Norwegian Lundehund
      Norwich Terrier
      Nova Scotia Duck Tolling Retriever
      Old English Sheepdog
      Otterhound
      Papillon
      Parson Russell Terrier
      Pekingese
      Pembroke Welsh Corgi
      Perro de Presa Canario
      Petit Basset Griffon Vendeen
      Pharaoh Hound
      Podenco Canario
      Pointer
      Polish Greyhound
      Polish Lowland Sheepdog
      Pomeranian
      Portuguese Podengo Médio
      Portuguese Podengo Pequeno
      Portuguese Water Dog
      Pug
      Puli
      Pumi
      Pyrenean Shepherd
      Rhodesian Ridgeback
      Rottweiler
      Russell Terrier
      Saint Bernard
      Saluki
      Samoyed
      Schipperke
      Scottish Deerhound
      Scottish Terrier
      Sealyham Terrier
      Shetland Sheepdog
      Shiba Inu
      Shih Tzu
      Siberian Husky
      Silky Terrier
      Skye Terrier
      Sloughi
      Small Münsterlander
      Smooth Fox Terrier
      Soft Coated Wheaten Terrier
      Spanish Greyhound
      Spanish Water Dog
      Spinone Italiano
      Staffordshire Bull Terrier
      Standard Poodle
      Standard Schnauzer
      Sussex Spaniel
      Swedish Vallhund
      Tibetan Mastiff
      Tibetan Spaniel
      Tibetan Terrier
      Toy Fox Terrier
      Toy Manchester Terrier
      Toy Poodle
      Treeing Walker Coonhound
      Vizsla
      Weimaraner
      Welsh Springer Spaniel
      Welsh Terrier
      West Highland White Terrier
      Whippet
      Wire Fox Terrier
      Wirehaired Pointing Griffon
      Wirehaired Vizsla
      Yorkshire Terrier

    Foreign Dogs?+

    Is your dog from a country outside the contiguous US, UK, Canada, Australia or Germany?

    The Wisdom Panel test was developed using pure breeds primarily from those found on The Kennel Club and the American Kennel Club registry lists. If your dog was imported from a country other than Canada, the UK, Australia, Germany, or mainland U.S., or you suspect that your dog’s ancestors are from outside these countries, his breed ancestry may not be well represented in our database.

    Instructions+

    1
    OPEN SWAB SLEEVE – Peel back the edges of the swab sleeve about 3 centimetres (not all the way) and remove swab by holding its handle. Do not touch the bristles. Save the sleeve to place the swabs in for mailing.
    2
    COLLECT CHEEK CELLS – Firmly roll the swab’s bristles between the inner surface of the cheek and gums for about 15 seconds for each swab. NOTE: DO NOT let your dog eat anything or share a water dish with other dogs for about an hour before you do the test.
    3
    AIR DRY SWABS – Allow swabs to dry for about five minutes. Repeat steps 1-3 for the second swab.
    4
    ACTIVATE YOUR KIT – Visit www.wisdompanel.co.uk and click on the “Activate You Kit” button at the top of the page. Fill out all the information, check it for accuracy and submit. You will receive an Activation Code Number that you need to write on the back of your Sample ID Sticker.
    5
    APPLY SAMPLE ID STICKER – Complete the label with your Activation Code Number and apply it to the back of the swab sleeve.
    6
    REINSERT DRY SWABS – Reinsert both dry swabs into the protective sleeve they came in. DO NOT reseal as this can cause bacterial growth.
    7
    SEAL THE  ENVELOPE – Place the sleeve with the swabs back into the carton it came in and seal. 
    8
    MAIL TEST TO LAB – Apply the included pre-paid shipping label and place with the outgoing mail. IN APPROXIMATELY 2-3 WEEKS FROM THE TIME THE SAMPLE REACHES THE LAB YOU WILL BE EMAILED A LINK TO VIEW YOUR REPORT.