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Wisdom Panel 2.0
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Wisdom Panel® 3.0

Available EXCLUSIVELY on WisdomPanel.co.uk

PRICE: £75.00
 

Description+

Discover the hidden secrets in your dog's DNA with the world's leading canine DNA test. Wisdom Panel 3.0 Canine DNA Test provides you with unprecedented accuracy to detect the breeds in your dog's ancestry as well as the important health screen for drug sensitivity (MDR1). Your dog's unique web site results portal will provide you with:

  1. Identification of purebred ancestors present in the first three generations (to the great-grandparent level)
  2. Extensive information about each breed found - behavior, traits, history
  3. A predicted weight profile
  4. Results for the drug-sensitivity genetic mutation, MDR1


Wisdom Panel 3.0 tests feature the largest breed coverage available in the U.K. with more than 220 breeds, types and varieties including all those recognized by The Kennel Club (KC). Your dog's test kit will include:

  • Instructions
  • DNA cheek swabs – all for use on one dog
  • Drying insert for swabs
  • Pre-paid shipping label and envelope

    Disease Testing – MDR1+

    For many years now Wisdom Panel has provided genetic mutation tests through our veterinary products and now we are including one of these important tests in our at-home swab product. Included in the Wisdom Panel™ 3.0 and 4.0 Canine Genetic Tests is the MDR1 genetic mutation test licensed from Washington State University, for use by Wisdom Health.


    MDR1 or Multi-Drug Resistance 1 is a genetic mutation found in many of the herding breeds, some sighthound breeds, and many mixed breed dogs. The MDR1 gene is responsible for production of a protein called P-glycoprotein. The P-glycoprotein molecule is a drug transport pump that plays an important role in limiting drug absorption and distribution (particularly to the brain) and enhancing the excretion/elimination of many drugs used in dogs.


    Some dogs, particularly herding breeds or mixed-breed dogs with herding breed ancestry have a mutation in the MDR1 gene that makes them defective in their ability to limit the absorption and distribution of many drugs. These dogs are also slower to eliminate drugs from the body that are transported by P-glycoprotein. As a result, dogs with the MDR1-mutation may have severe adverse reactions to some common drugs, so it is important to test your dog and share your results with your veterinarian so they can provide your dog with for the best possible care.


    What About Mixed-breed Dogs?
    Our tests look for the presence of purebreds in your dog’s heritage back to the great-grandparent level. Just because we don’t find a pedigree herding breed in your dog’s last three generations, however, doesn’t mean he or she doesn’t have one further back in their ancestry. Therefore, even mixed breed dogs should be tested for the MDR1 mutation. The results of this test can give owners with mixed-breed ancestry important information to share with their veterinarian or better yet…peace of mind.


    Drugs Affected By The MDR1 Mutation:

    • Acepromazine
    • Butorphanol
    • Doxorubicin
    • Doramectin
    • Emodepside
    • Erythromycin
    • Ivermectin
    • Loperamide
    • Milbemycin
    • Moxidectin
    • Paclitaxel
    • Rifampin
    • Selamectin
    • Vinblastine
    • Vincristine

      Drugs Affected By The MDR1 Mutation (frequency %)

      • Australian Shepherd 50%
      • Australian Shepherd, Mini 50%
      • Border Collie < 5%
      • Collie 70 %
      • English Shepherd 15 %
      • German Shepherd 10 %
      • Herding Breed Cross 10 %
      • Long-haired Whippet 65 %
      • McNab 30 %
      • Mixed Breed 5 %
      • Old English Sheepdog 5 %
      • Shetland Sheepdog 15 %
      • Silken Windhound 30 %
      FAQS ABOUT MDR1

      Can Collie crosses or other herding breed crosses carry the mutant MDR1 gene and have an adverse reaction to a normal dose of some drugs?

      Yes, it is less likely in a mixed breed, but still possible. For example, the mutant gene was found in a Saint Bernard mix that had an adverse drug reaction. The veterinarian did note that each eye was a different colour, like some Australian Shepherds.

      How old must a dog be before it can be tested?

      Just like breed testing, a puppy can be tested as soon as it is weaned from its mother. We recommend waiting until the puppy is weaned, because the sample is collected from inside the dog's mouth, and milk can contain a cells from the mother. Therefore, it is possible that the puppy's sample could contain enough of the mother’s DNA to generate a false result.

       

      Can mixed breed dogs have the MDR1 mutation?

      YES! The MDR1 mutation has been found in many mixed breed dogs - even dogs that don't look like herding breed dogs. In particular mixed breed dogs should be tested for the mutation before receiving therapies for some common parasitic diseases, such as Demodectic mange.

      What heartworm prevention products can I use if my dog has the MDR1 mutation?

      Always consult with your veterinarian before administering any drugs to your dog. Fortunately, the doses of ivermectin, selamectin, milbemycin and moxidectin in the FDA approved heartworm prevention preparations are low enough to be used safely even in dogs that have two copies of the MDR1 mutation. It is only when these drugs are administered at high doses that dogs with the mutation will develop signs of toxicity. Attempting to use formulations of these drugs approved for use in large animals will increase the risk of overdosing the dog and causing severe toxicity, because it is difficult to accurately measure the small doses needed for dogs using these large animal formulations.


      ORIGINS OF THE TEST

      The discovery of the mutation of the multi-drug resistant gene (MDR1) and its effects on multidrug sensitivity in dogs was made by Washington State University. It is a patent-protected diagnostic test offered by Washington State University that has been licensed to Wisdom Health for use in the Wisdom Panel tests.

      Breeds Detected+

      As the leader in canine breed detection, Wisdom Panel 3.0 features the largest breed database on the market providing superior accuracy in breed results.
       
      Don’t see your breed? Our database was developed using genetic markers from American Kennel Club (AKC) and Kennel Club breeds in the UK. If you believe your dog to be a breed or mix of breeds not found on this list note that his or her results may either show a mixed breed ancestor or the closest genetically related breed(s).
       
      • Affenpinscher
        Afghan Hound
        Airedale Terrier
        Akita
        Alaskan Klee Kai
        Alaskan Malamute
        American Bulldog
        American Eskimo Dog
        American Foxhound
        American Staffordshire Terrier
        American Water Spaniel
        Anatolian Shepherd Dog
        Argentine Dogo
        Australian Cattle Dog
        Australian Kelpie
        Australian Koolie
        Australian Shepherd
        Australian Terrier
        Azawakh
      • Barbet
        Basenji
        Basset Hound
        Beagle
        Bearded Collie
        Beauceron
        Bedlington Terrier
        Belgian Malinois
        Belgian Sheepdog
        Belgian Tervuren
        Bergamasco
        Berger Picard
        Bernese Mountain Dog
        Bichon Frise
        Biewer Terrier
        Black and Tan Coonhound
        Black Russian Terrier
        Bloodhound
        Bluetick Coonhound
        Bolognese
        Border Collie
        Border Terrier
        Borzoi
        Boston Terrier
        Bouvier des Flandres
        Boxer
        Boykin Spaniel
        Briard
        Brittany
        Brussels Griffon
        Bull Terrier
        Bulldog
        Bullmastiff
        Cairn Terrier
        Canaan Dog
      • Canadian Eskimo Dog
        Cane Corso
        Cardigan Welsh Corgi
        Cavalier King Charles Spaniel
        Cesky Terrier
        Chesapeake Bay Retriever
        Chihuahua
        Chinese Crested
        Chinese Shar-Pei
        Chinook
        Chow Chow
        Cirneco dell'Etna
        Clumber Spaniel
        Cocker Spaniel
        Collie
        Coton de Tulear
        Curly-Coated Retriever
        Dachshund Miniature Longhaired
        Dachshund Miniature Shorthaired
        Dachshund Miniature Wirehaired
        Dachshund Standard Longhaired
        Dachshund Standard Shorthaired
        Dachshund Standard Wirehaired
        Dalmatian
        Dandie Dinmont Terrier
        Doberman Pinscher
        Dogue de Bordeaux
      • Dutch Shepherd
        English Cocker Spaniel
        English Foxhound
        English Setter
        English Springer Spaniel
        English Toy Spaniel
        Entlebucher Mountain Dog
        Field Spaniel
        Finnish Lapphund
        Finnish Spitz
        Flat-Coated Retriever
        French Bulldog
        German Pinscher
        German Shepherd (White Swiss Shepherd)
        German Shepherd Dog
        German Shorthaired Pointer
        German Spitz
        German Wirehaired Pointer
        Giant Schnauzer
        Glen of Imaal Terrier
        Golden Retriever
        Gordon Setter
        Grand Basset Griffon Vendéen
        Great Dane
        Great Pyrenees
        Greater Swiss Mountain Dog
        Greyhound
        Harrier
        Havanese
      • Hovawart
        Ibizan Hound
        Icelandic Sheepdog
        Irish Red and White Setter
        Irish Setter
        Irish Terrier
        Irish Water Spaniel
        Irish Wolfhound
        Italian Greyhound
        Japanese Chin
        Japanese Spitz
        Jindo
        Keeshond
        Kerry Blue Terrier
        Komondor
      • Kooikerhondje
      • Kritikos Lagonikos
        Kuvasz
        Labrador Retriever
        Lagotto Romagnolo
        Lakeland Terrier
        Lancashire Heeler
        Large Münsterlander
        Leonberger
        Lhasa Apso
        Löwchen
        Magyar Agár
        Maltese
        Manchester Terrier
        Maremma Sheepdog
        Mastiff
        Mi-ki
      • Miniature American Shepherd
        Miniature Bull Terrier
        Miniature Pinscher
        Miniature Poodle
        Miniature Schnauzer
        Mudi
        Neapolitan Mastiff
        Newfoundland
        Norfolk Terrier
        Norwegian Buhund
        Norwegian Elkhound
        Norwegian Lundehund
        Norwich Terrier
        Nova Scotia Duck Tolling Retriever
        Old English Sheepdog
        Otterhound
        Papillon
        Parson Russell Terrier
        Pekingese
        Pembroke Welsh Corgi
        Perro de Presa Canario
        Petit Basset Griffon Vendeen
        Pharaoh Hound
        Podenco Canario
        Pointer
        Polish Greyhound
        Polish Lowland Sheepdog
        Pomeranian
        Portuguese Podengo Médio
        Portuguese Podengo Pequeno
        Portuguese Water Dog
        Pug
        Puli
        Pumi
        Pyrenean Shepherd
        Rhodesian Ridgeback
        Rottweiler
        Russell Terrier
      • Russian Tsvetnaya Bolonka
        Saint Bernard
        Saluki
        Samoyed
        Schipperke
        Scottish Deerhound
        Scottish Terrier
        Sealyham Terrier
        Shetland Sheepdog
        Shiba Inu
        Shih Tzu
        Siberian Husky
        Silky Terrier
        Skye Terrier
        Sloughi
        Small Münsterlander
        Smooth Fox Terrier
        Soft Coated Wheaten Terrier
        Spanish Greyhound
        Spanish Water Dog
        Spinone Italiano
        Staffordshire Bull Terrier
        Standard Poodle
        Standard Schnauzer
        Sussex Spaniel
        Swedish Vallhund
      • Taigan
        Tibetan Mastiff
        Tibetan Spaniel
        Tibetan Terrier
        Toy Fox Terrier
        Toy Manchester Terrier
        Toy Poodle
        Treeing Walker Coonhound
        Vizsla
        Weimaraner
        Welsh Springer Spaniel
        Welsh Terrier
        West Highland White Terrier
        Whippet
        Wire Fox Terrier
        Wirehaired Pointing Griffon
        Wirehaired Vizsla
        Yorkshire Terrier

      Foreign Dogs?+

      Is your dog from a country outside the contiguous US, UK, Canada, Australia or Germany?

      The Wisdom Panel test was developed using pure breeds primarily from those found on The Kennel Club and the American Kennel Club registry lists. If your dog was imported from a country other than Canada, the UK, Australia, Germany, or mainland U.S., or you suspect that your dog’s ancestors are from outside these countries, his breed ancestry may not be well represented in our database.

      Instructions+

      1
      OPEN SWAB SLEEVE – Peel back the edges of the swab sleeve about 3 centimetres (not all the way) and remove swab by holding its handle. Do not touch the bristles. Save the sleeve to place the swabs in for mailing.
      2
      COLLECT CHEEK CELLS – Firmly roll the swab’s bristles between the inner surface of the cheek and gums for about 15 seconds for each swab. NOTE: DO NOT let your dog eat anything or share a water dish with other dogs for about an hour before you do the test.
      3
      AIR DRY SWABS – Allow swabs to dry for about five minutes. Repeat steps 1-3 for the second swab.
      4
      ACTIVATE YOUR KIT – Visit www.wisdompanel.co.uk and click on the “Activate You Kit” button at the top of the page. Fill out all the information, check it for accuracy and submit. You will receive an Activation Code Number that you need to write on the back of your Sample ID Sticker.
      5
      APPLY SAMPLE ID STICKER – Complete the label with your Activation Code Number and apply it to the back of the swab sleeve.
      6
      REINSERT DRY SWABS – Reinsert both dry swabs into the protective sleeve they came in. DO NOT reseal as this can cause bacterial growth.
      7
      SEAL THE  ENVELOPE – Place the sleeve with the swabs back into the carton it came in and seal. 
      8
      MAIL TEST TO LAB – Apply the included pre-paid shipping label and place with the outgoing mail. IN APPROXIMATELY 2-3 WEEKS FROM THE TIME THE SAMPLE REACHES THE LAB YOU WILL BE EMAILED A LINK TO VIEW YOUR REPORT.